Applied and Environmental Microbiology为美国微生物学会会刊，列入浙江大学TOP期刊。该论文第一作者为博士生俞品，通讯作者为李永泉教授。Pin Yu, Shui-ping Liu, Qin-Ting Bu, Zhen-Xing Zhou, Zhen-Hong Zhu, Fang-Liang Huang ,  Yong-Quan Li*,  WblAch, a Pivotal Activator of Natamycin Biosynthesis and Morphological Differentiation in Streptomyces chattanoogensis L10, Is Positively Regulated by AdpAch, Applied and Environmental Microbiology,2014,80(22):6879-87，doi: 10.1128/AEM.01849-14doi: 10.1128/AEM.01849-14,

http://aem.asm.org/content/80/22/6879.full.pdf

    论文解析了恰塔努加链霉菌L10中whiB家族调控蛋白WblA_ch的调控机制。研究表明，WblA_ch在adpA_ch敲除株中表达量下降明显，qRT-PCR实验证实AdpA_ch正调控wblA_ch的转录，EMSA和DNaseI Footprinting 实验表明AdpA_ch直接结合在wblA_ch的启动子上；wblA_ch的缺失导致纳他霉素合成能力丧失，形态分化也受到严重影响，qRT-PCR实验表明whi基因在∆wblA_ch菌株中的低表达量可能是形态分化受阻的原因；从而揭示了wblA_ch与AdpA_ch耦联协同调控菌体细胞的形态分化与纳他霉素生物合成的分子机制。