Xin Chen

 

Ph.D., Professor, Vice Chair,
Department of Genetics and Bioinformatics,
College of Life Sciences, Zhejiang University,
866 Yuhangtang Rd., Xihu District,
Hangzhou, Zhejiang, P.R. China, 310058

Tel/Fax: (+86) 571-88208595
E-mail: xinchen@zju.edu.cn
Lab URL: http://www.cls.zju.edu.cn/rlibs/

 

Research Interests:

• Mechanisms and design principles of effective multi-component medicines
  
• Interaction / causal network analysis
  
• Molecular modeling and protein dynamics
  
• Biological knowledge representation and data mining
  
  

 

Academic Appointments:

2011-Present    Professor
                        Department of Genetics and Bioinformatics, Zhejiang University, P.R. China
2006-Present    Vice Chair
                        Department of Genetics and Bioinformatics, Zhejiang University, P.R. China
2005-2011        Associate Professor
                        Department of Genetics and Bioinformatics, Zhejiang University, P.R. China
2004-2005        Manager, High-throughput Biology
                        The Blueprint Initiative Asia Co. Ltd., Singapore
2002-2004        Junior Teaching Staff
                        Department of Biological Sciences, National University of Singapore, Singapore

 

Education:

2000    Dual B.Sc., Biotechnology and Computer Sciences;
            Shanghai Jiao Tong University, Shanghai, P.R. China.
2004    Ph.D., Computational Sciences;
            National University of Singapore, Singapore.

Selected Publications:

The full publication list can be found here.
*Corresponding author(s)

1. Lin M, Zhou X, Shen X, Mao C, Chen X*: The Predicted Arabidopsis Interactome Resource and Network Topology Based Systems Biology Analyses. The Plant Cell 2011, online.  [Link]

   Interaction network analysis; Systems biology

2. Liu Y, Hu B, Fu C, Chen X*: DCDB: drug combination database. Bioinformatics 2010, 26(4):587-588. [Link]

   Mechanisms of the concomitant multiple interventions of multi-component medicines

3. Shen X, Li S, Li Y*, Chen X*: Episodic sitewise positive selection on the signal recognition particle protein Ffh in Actinobacteria. FEBS Lett 2010, 584(18):3975-3978. [Link]

   Phylogenetics analysis

4. Zhou X, Li Y, Chen X*: Computational identification of bioactive natural products by structure activity relationship. J Mol Graph Model 2010, 29(1):38-45. [Link]

   Structure modeling for small molecules

5. Fan Y, Sun P, Wang Y, He X, Deng X, Chen X, Zhang G, Chen X*, Zhou N*: The G protein-coupled receptors in the silkworm, Bombyx mori. Insect Biochem Mol Biol 2010, 40(8):581-591. [Link]

   Genome analysis

6. Lin M, Hu B, Chen L, Sun P, Fan Y, Wu P, Chen X*: Computational identification of potential molecular interactions in Arabidopsis. Plant Physiol 2009, 151(1):34-46. [Link]

   Interaction network reconstruction

7. Chen S, Fan Y, Shen X, Sun P, Jiang G, Shen Y, Xue W, Li Y*, Chen X*: A molecular modeling study of the interaction between SRP-receptor complex and peptide translocon. Biochem Biophys Res Commun 2008, 377(2):346-350. [Link]

   Structure modeling for macromolecules

8. Xu H, Lin M, Wang W, Li Z, Huang J, Chen Y, Chen X*: Learning the drug target-likeness of a protein. Proteomics 2007, 7(23):4255-4263. [Link]

   Drug mechanism research

9. Chen X*, Zhou H, Liu Y, Wang J, Li H, Ung C, Han L, Cao Z, Chen Y*: Database of traditional Chinese medicine and its application to studies of mechanism and to prescription validation. Br J Pharmacol 2006, 149(8):1092-1103.[Link]

   Mechanisms of the concomitant multiple interventions of multi-component medicines

10. Chen X, Ung C, Chen Y*: Can an in silico drug-target search method be used to probe potential mechanisms of medicinal plant ingredients? Nat Prod Rep 2003, 20(4):432-444.[Link]

    Molecular docking; Drug mechanism research